P41T (p.Pro41Thr) variant of BRAF (P15056)
P41T (p.Pro41Thr) in BRAF (P15056) is a missense change. Clinical records from EBI and UniProt describe it as uncertain significance. The available variant effect predictions contribute to a CATVariant prioritization score of 0.56 / 1. The record also includes population frequency data, experimental measurements, and structural context.
P41T (p.Pro41Thr) variant details
- p.Pro41Thr
- TOPMed rs1389368234
- gnomAD rs1389368234
- Uncertain significance
- Missense
- Variant Prioritization Score for Impact Estimate 0.556
- MetaLR 0.23
- MetaSVM -0.78
- CADD 23.10
- PolyPhen-2 0.14
- SIFT 0.03
- EBI: Variant of uncertain significance
- UniProt: Uncertain significance
- Population evidence available
- Structural context available
- BRAF Raf-like Ras-binding domain domainome 1.0: score -0.109