P25T (p.Pro25Thr) variant of BRAF (P15056)
P25T (p.Pro25Thr) in BRAF (P15056) is a missense change. Clinical records from ClinVar, EBI, and UniProt describe it as uncertain significance in the context of not provided. The available variant effect predictions contribute to a CATVariant prioritization score of 0.38 / 1. The record also includes population frequency data, experimental measurements, and structural context.
P25T (p.Pro25Thr) variant details
- p.Pro25Thr
- rs730880412
- ClinGen CA295919
- ClinVar RCV000157827
- TOPMed rs730880412
- Uncertain significance
- not provided
- Missense
- Variant Prioritization Score for Impact Estimate 0.381
- MetaLR 0.20
- MetaSVM -0.91
- CADD 18.60
- PolyPhen-2 0.09
- SIFT 0.05
- ClinVar: Uncertain significance (not provided)
- EBI: Variant of uncertain significance
- UniProt: Uncertain significance
- Population evidence available
- Structural context available
- BRAF Raf-like Ras-binding domain domainome 1.0: score -1.25