G8V (p.Gly8Val) variant of BRAF (P15056)
G8V (p.Gly8Val) in BRAF (P15056) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.55 / 1. The record also includes population frequency data, experimental measurements, and structural context.
G8V (p.Gly8Val) variant details
- p.Gly8Val
- cosmic curated COSV56106
- ExAC rs774925605
- gnomAD rs774925605
- Missense
- Variant Prioritization Score for Impact Estimate 0.553
- MetaLR 0.20
- MetaSVM -0.86
- CADD 22.10
- PolyPhen-2 1.00
- SIFT 0.00
- Most common in the Non-Finnish European population (allele frequency 5.8e-05)
- Structural context available
- BRAF Raf-like Ras-binding domain domainome 1.0: score 0.0307