G6C (p.Gly6Cys) variant of BRAF (P15056)
G6C (p.Gly6Cys) in BRAF (P15056) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.41 / 1. The record also includes population frequency data, experimental measurements, and structural context.
G6C (p.Gly6Cys) variant details
- p.Gly6Cys
- TOPMed rs1209990009
- gnomAD rs1209990009
- Missense
- Variant Prioritization Score for Impact Estimate 0.409
- MetaLR 0.15
- MetaSVM -0.97
- CADD 22.60
- PolyPhen-2 1.00
- SIFT 0.00
- Most common in the Non-Finnish European population (allele frequency 5e-05)
- Structural context available
- BRAF Raf-like Ras-binding domain domainome 1.0: score -0.156