G28A (p.Gly28Ala) variant of BRAF (P15056)
G28A (p.Gly28Ala) in BRAF (P15056) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.35 / 1. The record also includes population frequency data, experimental measurements, and structural context.
G28A (p.Gly28Ala) variant details
- p.Gly28Ala
- Ensembl rs2129153281
- Missense
- Variant Prioritization Score for Impact Estimate 0.348
- MetaLR 0.20
- MetaSVM -0.88
- CADD 17.50
- PolyPhen-2 0.00
- SIFT 0.12
- Most common in the Ashkenazi Jewish population (allele frequency 7.7e-05)
- Structural context available
- BRAF Raf-like Ras-binding domain domainome 1.0: score -0.76