E45K (p.Glu45Lys) variant of BRAF (P15056)
E45K (p.Glu45Lys) in BRAF (P15056) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.50 / 1. The record also includes population frequency data, experimental measurements, and structural context.
E45K (p.Glu45Lys) variant details
- p.Glu45Lys
- cosmic curated COSV56146
- Ensembl rs2129153125
- Missense
- Variant Prioritization Score for Impact Estimate 0.504
- MetaLR 0.31
- MetaSVM -0.49
- CADD 23.30
- PolyPhen-2 0.01
- SIFT 0.07
- Population evidence available
- Structural context available
- BRAF Raf-like Ras-binding domain domainome 1.0: score -0.0522