E26Q (p.Glu26Gln) variant of BRAF (P15056)
E26Q (p.Glu26Gln) in BRAF (P15056) is a missense change. Clinical records from EBI and UniProt describe it as likely benign. The available variant effect predictions contribute to a CATVariant prioritization score of 0.55 / 1. The record also includes population frequency data, experimental measurements, and structural context.
E26Q (p.Glu26Gln) variant details
- p.Glu26Gln
- Ensembl rs397507457
- Likely benign
- Missense
- Variant Prioritization Score for Impact Estimate 0.547
- AlphaMissense 0.20
- MetaLR 0.19
- MetaSVM -0.77
- CADD 21.50
- PolyPhen-2 0.78
- SIFT 0.07
- EBI: Likely benign
- UniProt: Likely benign
- Most common in the Non-Finnish European population (allele frequency 3.4e-06)
- Structural context available
- BRAF Raf-like Ras-binding domain domainome 1.0: score -0.035