E24K (p.Glu24Lys) variant of BRAF (P15056)
E24K (p.Glu24Lys) in BRAF (P15056) is a missense change. Clinical records from ClinVar, EBI, and UniProt describe it as uncertain significance in the context of not provided. The available variant effect predictions contribute to a CATVariant prioritization score of 0.34 / 1. The record also includes experimental measurements and structural context.
E24K (p.Glu24Lys) variant details
- p.Glu24Lys
- rs730880416
- ClinGen CA295916
- ClinVar RCV000157826
- Ensembl rs730880416
- Uncertain significance
- not provided
- Missense
- Variant Prioritization Score for Impact Estimate 0.335
- AlphaMissense 0.61
- MetaLR 0.19
- MetaSVM -0.87
- PolyPhen-2 0.01
- SIFT 0.13
- MutPred 0.21
- ClinVar: Uncertain significance (not provided)
- EBI: Variant of uncertain significance
- UniProt: Uncertain significance
- Structural context available
- BRAF Raf-like Ras-binding domain domainome 1.0: score -0.167