A91S (p.Ala91Ser) variant of BRAF (P15056)
A91S (p.Ala91Ser) in BRAF (P15056) is a missense change. Clinical records from ClinVar, EBI, and UniProt describe it as uncertain significance in the context of BRAF-related spectrum disorder. The available variant effect predictions contribute to a CATVariant prioritization score of 0.37 / 1. The record also includes structural context.
A91S (p.Ala91Ser) variant details
- p.Ala91Ser
- rs2129062291
- ClinGen CA369593904
- cosmic curated COSV10517
- ClinVar RCV001795611
- Uncertain significance
- BRAF-related spectrum disorder
- Missense
- Variant Prioritization Score for Impact Estimate 0.375
- AlphaMissense 1.00
- MetaLR 0.24
- MetaSVM -0.54
- PolyPhen-2 0.92
- SIFT 0.09
- MutPred 0.35
- ClinVar: Uncertain significance (BRAF-related spectrum disorder)
- EBI: Variant of uncertain significance
- UniProt: Uncertain significance
- Structural context available