A34S (p.Ala34Ser) variant of BRAF (P15056)
A34S (p.Ala34Ser) in BRAF (P15056) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.35 / 1. The record also includes population frequency data, experimental measurements, and structural context.
A34S (p.Ala34Ser) variant details
- p.Ala34Ser
- Ensembl rs2129153220
- Missense
- Variant Prioritization Score for Impact Estimate 0.345
- MetaLR 0.13
- MetaSVM -0.97
- CADD 13.30
- PolyPhen-2 0.01
- SIFT 0.28
- Most common in the Non-Finnish European population (allele frequency 1.8e-06)
- Structural context available
- BRAF Raf-like Ras-binding domain domainome 1.0: score -0.04