A33T (p.Ala33Thr) variant of BRAF (P15056)
A33T (p.Ala33Thr) in BRAF (P15056) is a missense change. Clinical records from EBI and UniProt describe it as uncertain significance. The available variant effect predictions contribute to a CATVariant prioritization score of 0.44 / 1. The record also includes population frequency data, experimental measurements, and structural context.
A33T (p.Ala33Thr) variant details
- p.Ala33Thr
- cosmic curated COSV56189
- TOPMed rs1458837905
- gnomAD rs1458837905
- Uncertain significance
- Missense
- Variant Prioritization Score for Impact Estimate 0.439
- MetaLR 0.14
- MetaSVM -1.02
- CADD 15.40
- PolyPhen-2 0.01
- SIFT 0.40
- EBI: Variant of uncertain significance
- UniProt: Uncertain significance
- Population evidence available
- Structural context available
- BRAF Raf-like Ras-binding domain domainome 1.0: score -0.442