A31P (p.Ala31Pro) variant of BRAF (P15056)
A31P (p.Ala31Pro) in BRAF (P15056) is a missense change. Clinical records from EBI and UniProt describe it as uncertain significance. The available variant effect predictions contribute to a CATVariant prioritization score of 0.28 / 1. The record also includes population frequency data, experimental measurements, and structural context.
A31P (p.Ala31Pro) variant details
- p.Ala31Pro
- Ensembl rs2129153255
- Uncertain significance
- Missense
- Variant Prioritization Score for Impact Estimate 0.277
- MetaLR 0.18
- MetaSVM -0.93
- CADD 21.90
- PolyPhen-2 0.00
- SIFT 0.18
- EBI: Variant of uncertain significance
- UniProt: Uncertain significance
- Most common in the Non-Finnish European population (allele frequency 3.4e-06)
- Structural context available
- BRAF Raf-like Ras-binding domain domainome 1.0: score -0.17