T59S (p.Thr59Ser) variant of BIN1 (O00499)
T59S (p.Thr59Ser) in BIN1 (O00499) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.33 / 1. The record also includes population frequency data and structural context.
T59S (p.Thr59Ser) variant details
- p.Thr59Ser
- ExAC rs755973108
- TOPMed rs755973108
- gnomAD rs755973108
- Missense
- Variant Prioritization Score for Impact Estimate 0.329
- REVEL 0.06
- CADD 19.30
- PolyPhen-2 0.12
- SIFT 0.70
- Most common in the South Asian population (allele frequency 1.2e-05)
- Structural context available