G41R (p.Gly41Arg) variant of BDNF (P23560)
G41R (p.Gly41Arg) in BDNF (P23560) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.56 / 1. The record also includes population frequency data.
G41R (p.Gly41Arg) variant details
- p.Gly41Arg
- ExAC rs773773442
- gnomAD rs773773442
- NCI-TCGA Cosmic COSV1001
- cosmic curated COSV10015
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.56
- REVEL 0.40
- CADD 24.20
- PolyPhen-2 0.99
- SIFT 0.13
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the Non-Finnish European population (allele frequency 9e-06)