S74L (p.Ser74Leu) variant of BCL2L2 (Bcl-2-like protein 2)
S74L (p.Ser74Leu) in BCL2L2 (Bcl-2-like protein 2) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.40 / 1. The record also includes population frequency data and structural context.
S74L (p.Ser74Leu) variant details
- p.Ser74Leu
- cosmic curated COSV51635
- TOPMed rs1392749158
- gnomAD rs1392749158
- Missense
- Variant Prioritization Score for Impact Estimate 0.404
- REVEL 0.14
- CADD 24.70
- PolyPhen-2 0.33
- SIFT 0.05
- Most common in the Non-Finnish European population (allele frequency 1.5e-05)
- Structural context available