R59H (p.Arg59His) variant of BCL2L2 (Bcl-2-like protein 2)
R59H (p.Arg59His) in BCL2L2 (Bcl-2-like protein 2) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.33 / 1. The record also includes population frequency data and structural context.
R59H (p.Arg59His) variant details
- p.Arg59His
- rs372109088
- cosmic curated COSV51636
- 1000Genomes rs372109088
- ESP rs372109088
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.328
- REVEL 0.11
- CADD 23.40
- PolyPhen-2 0.10
- SIFT 0.06
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the 1KG:ITU population (allele frequency 0.0049)
- Structural context available