R47W (p.Arg47Trp) variant of BCL2L2 (Bcl-2-like protein 2)
R47W (p.Arg47Trp) in BCL2L2 (Bcl-2-like protein 2) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.43 / 1. The record also includes population frequency data and structural context.
R47W (p.Arg47Trp) variant details
- p.Arg47Trp
- rs1355053032
- NCI-TCGA Cosmic COSV9916
- cosmic curated COSV99161
- TOPMed rs1355053032
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.429
- REVEL 0.33
- CADD 26.30
- PolyPhen-2 1.00
- SIFT 0.00
- UniProt: Variant assessed as somatic; moderate impact.
- Population evidence available
- Structural context available