P26S (p.Pro26Ser) variant of BCL2L11 (Bcl-2-like protein 11)
P26S (p.Pro26Ser) in BCL2L11 (Bcl-2-like protein 11) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.21 / 1. The record also includes population frequency data and structural context.
P26S (p.Pro26Ser) variant details
- p.Pro26Ser
- rs762820125
- NCI-TCGA Cosmic COSV1004
- cosmic curated COSV10042
- ExAC rs762820125
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.207
- REVEL 0.05
- MetaLR 0.06
- MetaSVM -1.04
- CADD 17.30
- PolyPhen-2 0.00
- SIFT 0.26
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the Latino/Admixed American population (allele frequency 3.3e-05)
- Structural context available