P26L (p.Pro26Leu) variant of BCL2L11 (Bcl-2-like protein 11)
P26L (p.Pro26Leu) in BCL2L11 (Bcl-2-like protein 11) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.25 / 1. The record also includes population frequency data and structural context.
P26L (p.Pro26Leu) variant details
- p.Pro26Leu
- rs375839187
- NCI-TCGA Cosmic COSV1004
- cosmic curated COSV10042
- TOPMed rs375839187
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.252
- REVEL 0.08
- MetaLR 0.08
- MetaSVM -0.98
- CADD 22.80
- PolyPhen-2 0.06
- SIFT 0.11
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the African/African-American population (allele frequency 0.00027)
- Structural context available