E51K (p.Glu51Lys) variant of BCL2L11 (Bcl-2-like protein 11)
E51K (p.Glu51Lys) in BCL2L11 (Bcl-2-like protein 11) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.27 / 1. The record also includes population frequency data and structural context.
E51K (p.Glu51Lys) variant details
- p.Glu51Lys
- NCI-TCGA Cosmic COSV5802
- cosmic curated COSV58027
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.267
- REVEL 0.05
- CADD 23.50
- PolyPhen-2 0.03
- SIFT 0.05
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the Non-Finnish European population (allele frequency 9e-07)
- Structural context available