A2S (p.Ala2Ser) variant of BCL2L11 (Bcl-2-like protein 11)
A2S (p.Ala2Ser) in BCL2L11 (Bcl-2-like protein 11) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.45 / 1. The record also includes population frequency data, published literature, and structural context.
A2S (p.Ala2Ser) variant details
- p.Ala2Ser
- gnomAD 2-111123749-G-T
- Missense
- Variant Prioritization Score for Impact Estimate 0.454
- REVEL 0.27
- MetaLR 0.26
- MetaSVM -0.52
- CADD 26.90
- PolyPhen-2 0.97
- SIFT 0.00
- Most common in the South Asian population (allele frequency 2.4e-05)
- Structural context available
- Literature evidence available