S25N (p.Ser25Asn) variant of BCL2L1 (Bcl-2-like protein 1)
S25N (p.Ser25Asn) in BCL2L1 (Bcl-2-like protein 1) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.30 / 1. The record also includes population frequency data and structural context.
S25N (p.Ser25Asn) variant details
- p.Ser25Asn
- NCI-TCGA TCGA novel
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.3
- REVEL 0.06
- CADD 21.20
- PolyPhen-2 0.01
- SIFT 0.34
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the African/African-American population (allele frequency 3.3e-05)
- Structural context available