V35M (p.Val35Met) variant of BCL2 (Apoptosis regulator Bcl-2)
V35M (p.Val35Met) in BCL2 (Apoptosis regulator Bcl-2) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.15 / 1. The record also includes population frequency data and structural context.
V35M (p.Val35Met) variant details
- p.Val35Met
- cosmic curated COSV61383
- ExAC rs775108608
- TOPMed rs775108608
- gnomAD rs775108608
- Missense
- Variant Prioritization Score for Impact Estimate 0.146
- REVEL 0.05
- MetaLR 0.01
- MetaSVM -1.02
- CADD 12.80
- PolyPhen-2 0.02
- SIFT 0.12
- Most common in the South Asian population (allele frequency 3.5e-05)
- Structural context available