L23M (p.Leu23Met) variant of BCL2 (Apoptosis regulator Bcl-2)
L23M (p.Leu23Met) in BCL2 (Apoptosis regulator Bcl-2) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.45 / 1. The record also includes population frequency data and structural context.
L23M (p.Leu23Met) variant details
- p.Leu23Met
- gnomAD rs1441603213
- Missense
- Variant Prioritization Score for Impact Estimate 0.452
- REVEL 0.37
- MetaLR 0.06
- MetaSVM -1.16
- CADD 26.00
- PolyPhen-2 1.00
- SIFT 0.00
- Most common in the Latino/Admixed American population (allele frequency 2.2e-05)
- Structural context available