G15D (p.Gly15Asp) variant of BAG3 (O95817)
G15D (p.Gly15Asp) in BAG3 (O95817) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.43 / 1. The record also includes population frequency data, experimental measurements, and structural context.
G15D (p.Gly15Asp) variant details
- p.Gly15Asp
- NCI-TCGA Cosmic COSV6484
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.435
- REVEL 0.23
- CADD 26.40
- PolyPhen-2 0.74
- SIFT 0.01
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the Non-Finnish European population (allele frequency 3.4e-06)
- Structural context available
- BAG3 WW domain domainome 1.0: score -0.0966