Y24C (p.Tyr24Cys) variant of ARAF (P10398)
Y24C (p.Tyr24Cys) in ARAF (P10398) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.69 / 1. The record also includes population frequency data, experimental measurements, published literature, and structural context.
Y24C (p.Tyr24Cys) variant details
- p.Tyr24Cys
- gnomAD X-47563038-A-G
- Missense
- Variant Prioritization Score for Impact Estimate 0.691
- REVEL 0.78
- CADD 25.90
- PolyPhen-2 0.99
- SIFT 0.05
- Population evidence available
- Structural context available
- ARAF Raf-like Ras-binding domain domainome 1.0: score -0.487
- Literature evidence available