V51L (p.Val51Leu) variant of ARAF (P10398)
V51L (p.Val51Leu) in ARAF (P10398) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.50 / 1. The record also includes population frequency data, experimental measurements, and structural context.
V51L (p.Val51Leu) variant details
- p.Val51Leu
- gnomAD rs1214099265
- Missense
- Variant Prioritization Score for Impact Estimate 0.504
- REVEL 0.39
- CADD 21.70
- PolyPhen-2 0.17
- SIFT 0.75
- Most common in the South Asian population (allele frequency 1.9e-05)
- Structural context available
- ARAF Raf-like Ras-binding domain domainome 1.0: score -0.255