V41I (p.Val41Ile) variant of ARAF (P10398)
V41I (p.Val41Ile) in ARAF (P10398) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.51 / 1. The record also includes population frequency data, experimental measurements, and structural context.
V41I (p.Val41Ile) variant details
- p.Val41Ile
- NCI-TCGA Cosmic COSV9928
- cosmic curated COSV99283
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.515
- REVEL 0.40
- CADD 23.20
- PolyPhen-2 0.38
- SIFT 0.02
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the South Asian population (allele frequency 1.9e-05)
- Structural context available
- ARAF Raf-like Ras-binding domain domainome 1.0: score -0.938