V23L (p.Val23Leu) variant of ARAF (P10398)
V23L (p.Val23Leu) in ARAF (P10398) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.75 / 1. The record also includes population frequency data, experimental measurements, and structural context.
V23L (p.Val23Leu) variant details
- p.Val23Leu
- NCI-TCGA Cosmic COSV9928
- cosmic curated COSV99283
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.755
- REVEL 0.79
- CADD 26.10
- PolyPhen-2 1.00
- SIFT 0.01
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the Non-Finnish European population (allele frequency 1.2e-06)
- Structural context available
- ARAF Raf-like Ras-binding domain domainome 1.0: score -0.825