V21A (p.Val21Ala) variant of ARAF (P10398)
V21A (p.Val21Ala) in ARAF (P10398) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.64 / 1. The record also includes population frequency data, experimental measurements, published literature, and structural context.
V21A (p.Val21Ala) variant details
- p.Val21Ala
- gnomAD X-47563029-T-C
- Missense
- Variant Prioritization Score for Impact Estimate 0.636
- REVEL 0.69
- CADD 25.60
- PolyPhen-2 0.49
- SIFT 0.00
- Population evidence available
- Structural context available
- ARAF Raf-like Ras-binding domain domainome 1.0: score -0.0327
- Literature evidence available