T70M (p.Thr70Met) variant of ARAF (P10398)
T70M (p.Thr70Met) in ARAF (P10398) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.44 / 1. The record also includes population frequency data and structural context.
T70M (p.Thr70Met) variant details
- p.Thr70Met
- rs199527940
- NCI-TCGA Cosmic COSV5169
- cosmic curated COSV51691
- 1000Genomes rs199527940
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.439
- REVEL 0.35
- CADD 21.30
- PolyPhen-2 0.23
- SIFT 0.13
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the 1KG:CHB population (allele frequency 0.0064)
- Structural context available