T34I (p.Thr34Ile) variant of ARAF (P10398)
T34I (p.Thr34Ile) in ARAF (P10398) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.43 / 1. The record also includes population frequency data, experimental measurements, and structural context.
T34I (p.Thr34Ile) variant details
- p.Thr34Ile
- TOPMed rs975645936
- gnomAD rs975645936
- Missense
- Variant Prioritization Score for Impact Estimate 0.434
- REVEL 0.33
- CADD 22.50
- PolyPhen-2 0.20
- SIFT 0.14
- Most common in the Non-Finnish European population (allele frequency 1.5e-05)
- Structural context available
- ARAF Raf-like Ras-binding domain domainome 1.0: score -0.459