S40T (p.Ser40Thr) variant of ARAF (P10398)
S40T (p.Ser40Thr) in ARAF (P10398) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.41 / 1. The record also includes population frequency data, experimental measurements, published literature, and structural context.
S40T (p.Ser40Thr) variant details
- p.Ser40Thr
- gnomAD X-47563248-G-C
- Missense
- Variant Prioritization Score for Impact Estimate 0.409
- REVEL 0.26
- CADD 16.70
- PolyPhen-2 0.04
- SIFT 1.00
- Population evidence available
- Structural context available
- ARAF Raf-like Ras-binding domain domainome 1.0: score -0.273
- Literature evidence available