S15Y (p.Ser15Tyr) variant of ARAF (P10398)
S15Y (p.Ser15Tyr) in ARAF (P10398) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.49 / 1. The record also includes population frequency data, experimental measurements, published literature, and structural context.
S15Y (p.Ser15Tyr) variant details
- p.Ser15Tyr
- gnomAD X-47563011-C-A
- Missense
- Variant Prioritization Score for Impact Estimate 0.491
- REVEL 0.50
- CADD 22.80
- PolyPhen-2 0.84
- SIFT 0.01
- Population evidence available
- Structural context available
- ARAF Raf-like Ras-binding domain domainome 1.0: score -0.549
- Literature evidence available