R68Q (p.Arg68Gln) variant of ARAF (P10398)
R68Q (p.Arg68Gln) in ARAF (P10398) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.45 / 1. The record also includes population frequency data, experimental measurements, and structural context.
R68Q (p.Arg68Gln) variant details
- p.Arg68Gln
- cosmic curated COSV51695
- gnomAD rs1410667957
- Missense
- Variant Prioritization Score for Impact Estimate 0.452
- REVEL 0.34
- CADD 23.60
- PolyPhen-2 0.62
- SIFT 0.30
- Most common in the Non-Finnish European population (allele frequency 1.9e-05)
- Structural context available
- ARAF Raf-like Ras-binding domain domainome 1.0: score -0.127