R68L (p.Arg68Leu) variant of ARAF (P10398)
R68L (p.Arg68Leu) in ARAF (P10398) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.58 / 1. The record also includes population frequency data, experimental measurements, and structural context.
R68L (p.Arg68Leu) variant details
- p.Arg68Leu
- gnomAD rs1410667957
- Missense
- Variant Prioritization Score for Impact Estimate 0.579
- REVEL 0.57
- CADD 24.00
- PolyPhen-2 0.95
- SIFT 0.07
- Most common in the African/African-American population (allele frequency 3.8e-05)
- Structural context available
- ARAF Raf-like Ras-binding domain domainome 1.0: score -0.127