R68* (p.Arg68Ter) variant of ARAF (P10398)
R68* (p.Arg68Ter) in ARAF (P10398) is a protein-truncating change. Clinical records from UniProt describe it as variant assessed as somatic; high impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.38 / 1. The record also includes population frequency data, experimental measurements, and structural context.
R68* (p.Arg68Ter) variant details
- p.Arg68Ter
- NCI-TCGA Cosmic COSV5169
- cosmic curated COSV51692
- Variant assessed as somatic; high impact.
- Stop Gained
- Variant Prioritization Score for Impact Estimate 0.377
- CADD 33.00
- UniProt: Variant assessed as somatic; high impact.
- Most common in the South Asian population (allele frequency 1.9e-05)
- Structural context available
- ARAF Raf-like Ras-binding domain domainome 1.0: score -0.127