R63Q (p.Arg63Gln) variant of ARAF (P10398)
R63Q (p.Arg63Gln) in ARAF (P10398) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.74 / 1. The record also includes population frequency data, experimental measurements, and structural context.
R63Q (p.Arg63Gln) variant details
- p.Arg63Gln
- rs1413219188
- NCI-TCGA Cosmic COSV5169
- cosmic curated COSV51695
- TOPMed rs1413219188
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.736
- REVEL 0.74
- CADD 28.50
- PolyPhen-2 0.91
- SIFT 0.01
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the East Asian population (allele frequency 3.3e-05)
- Structural context available
- ARAF Raf-like Ras-binding domain domainome 1.0: score -0.376