R63* (p.Arg63Ter) variant of ARAF (P10398)
R63* (p.Arg63Ter) in ARAF (P10398) is a protein-truncating change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.48 / 1. The record also includes population frequency data, experimental measurements, published literature, and structural context.
R63* (p.Arg63Ter) variant details
- p.Arg63Ter
- gnomAD X-47563316-C-T
- Stop Gained
- Variant Prioritization Score for Impact Estimate 0.476
- CADD 35.00
- Most common in the Non-Finnish European population (allele frequency 2.4e-06)
- Structural context available
- ARAF Raf-like Ras-binding domain domainome 1.0: score -0.376
- Literature evidence available