R5W (p.Arg5Trp) variant of ARAF (P10398)
R5W (p.Arg5Trp) in ARAF (P10398) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.47 / 1. The record also includes population frequency data, experimental measurements, and structural context.
R5W (p.Arg5Trp) variant details
- p.Arg5Trp
- ExAC rs767772118
- TOPMed rs767772118
- gnomAD rs767772118
- Missense
- Variant Prioritization Score for Impact Estimate 0.472
- REVEL 0.47
- CADD 24.30
- PolyPhen-2 0.59
- SIFT 0.00
- Most common in the Non-Finnish European population (allele frequency 1.1e-05)
- Structural context available
- ARAF Raf-like Ras-binding domain domainome 1.0: score 0.113