R5Q (p.Arg5Gln) variant of ARAF (P10398)
R5Q (p.Arg5Gln) in ARAF (P10398) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.46 / 1. The record also includes population frequency data, experimental measurements, and structural context.
R5Q (p.Arg5Gln) variant details
- p.Arg5Gln
- cosmic curated COSV51691
- TOPMed rs1048525052
- gnomAD rs1048525052
- Missense
- Variant Prioritization Score for Impact Estimate 0.465
- REVEL 0.32
- CADD 22.80
- PolyPhen-2 0.30
- SIFT 0.10
- Most common in the Non-Finnish European population (allele frequency 3.8e-05)
- Structural context available
- ARAF Raf-like Ras-binding domain domainome 1.0: score 0.113