R52W (p.Arg52Trp) variant of ARAF (P10398)
R52W (p.Arg52Trp) in ARAF (P10398) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.64 / 1. The record also includes population frequency data, experimental measurements, and structural context.
R52W (p.Arg52Trp) variant details
- p.Arg52Trp
- cosmic curated COSV51693
- Ensembl rs2147902794
- Missense
- Variant Prioritization Score for Impact Estimate 0.643
- REVEL 0.79
- CADD 25.60
- PolyPhen-2 1.00
- SIFT 0.00
- Most common in the Non-Finnish European population (allele frequency 1.2e-06)
- Structural context available
- ARAF Raf-like Ras-binding domain domainome 1.0: score -0.188