R36W (p.Arg36Trp) variant of ARAF (P10398)
R36W (p.Arg36Trp) in ARAF (P10398) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.80 / 1. The record also includes population frequency data, experimental measurements, and structural context.
R36W (p.Arg36Trp) variant details
- p.Arg36Trp
- TOPMed rs1283082877
- Missense
- Variant Prioritization Score for Impact Estimate 0.803
- REVEL 0.86
- CADD 28.00
- PolyPhen-2 1.00
- SIFT 0.02
- Most common in the South Asian population (allele frequency 1.9e-05)
- Structural context available
- ARAF Raf-like Ras-binding domain domainome 1.0: score -0.169