R30C (p.Arg30Cys) variant of ARAF (P10398)
R30C (p.Arg30Cys) in ARAF (P10398) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.74 / 1. The record also includes population frequency data, experimental measurements, and structural context.
R30C (p.Arg30Cys) variant details
- p.Arg30Cys
- cosmic curated COSV51695
- Missense
- Variant Prioritization Score for Impact Estimate 0.741
- REVEL 0.73
- CADD 33.00
- PolyPhen-2 0.46
- SIFT 0.01
- Population evidence available
- Structural context available
- ARAF Raf-like Ras-binding domain domainome 1.0: score -0.403