P4S (p.Pro4Ser) variant of ARAF (P10398)
P4S (p.Pro4Ser) in ARAF (P10398) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.21 / 1. The record also includes population frequency data, experimental measurements, and structural context.
P4S (p.Pro4Ser) variant details
- p.Pro4Ser
- gnomAD rs1159713948
- Missense
- Variant Prioritization Score for Impact Estimate 0.209
- REVEL 0.15
- CADD 17.80
- PolyPhen-2 0.00
- SIFT 0.15
- Most common in the Latino/Admixed American population (allele frequency 9.4e-05)
- Structural context available
- ARAF Raf-like Ras-binding domain domainome 1.0: score -0.0453