P4R (p.Pro4Arg) variant of ARAF (P10398)
P4R (p.Pro4Arg) in ARAF (P10398) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.31 / 1. The record also includes population frequency data, experimental measurements, and structural context.
P4R (p.Pro4Arg) variant details
- p.Pro4Arg
- gnomAD rs1376896677
- Missense
- Variant Prioritization Score for Impact Estimate 0.307
- REVEL 0.26
- CADD 22.00
- PolyPhen-2 0.04
- SIFT 0.05
- Most common in the South Asian population (allele frequency 2e-05)
- Structural context available
- ARAF Raf-like Ras-binding domain domainome 1.0: score -0.0453