N10S (p.Asn10Ser) variant of ARAF (P10398)
N10S (p.Asn10Ser) in ARAF (P10398) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.22 / 1. The record also includes population frequency data, experimental measurements, and structural context.
N10S (p.Asn10Ser) variant details
- p.Asn10Ser
- ExAC rs776073253
- TOPMed rs776073253
- gnomAD rs776073253
- Missense
- Variant Prioritization Score for Impact Estimate 0.221
- REVEL 0.15
- CADD 17.10
- PolyPhen-2 0.03
- SIFT 0.51
- Most common in the Latino/Admixed American population (allele frequency 9.2e-05)
- Structural context available
- ARAF Raf-like Ras-binding domain domainome 1.0: score 0.051