M39V (p.Met39Val) variant of ARAF (P10398)
M39V (p.Met39Val) in ARAF (P10398) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.51 / 1. The record also includes population frequency data, experimental measurements, and structural context.
M39V (p.Met39Val) variant details
- p.Met39Val
- ExAC rs781331960
- gnomAD rs781331960
- Missense
- Variant Prioritization Score for Impact Estimate 0.505
- REVEL 0.51
- CADD 17.90
- PolyPhen-2 0.08
- SIFT 0.67
- Most common in the East Asian population (allele frequency 3.3e-05)
- Structural context available
- ARAF Raf-like Ras-binding domain domainome 1.0: score -0.493