L64F (p.Leu64Phe) variant of ARAF (P10398)
L64F (p.Leu64Phe) in ARAF (P10398) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.71 / 1. The record also includes population frequency data, experimental measurements, published literature, and structural context.
L64F (p.Leu64Phe) variant details
- p.Leu64Phe
- gnomAD X-47563319-C-T
- Missense
- Variant Prioritization Score for Impact Estimate 0.705
- REVEL 0.71
- CADD 23.60
- PolyPhen-2 1.00
- SIFT 0.20
- Population evidence available
- Structural context available
- ARAF Raf-like Ras-binding domain domainome 1.0: score -0.268
- Literature evidence available