L25Q (p.Leu25Gln) variant of ARAF (P10398)
L25Q (p.Leu25Gln) in ARAF (P10398) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.78 / 1. The record also includes population frequency data, experimental measurements, and structural context.
L25Q (p.Leu25Gln) variant details
- p.Leu25Gln
- gnomAD rs1431755155
- Missense
- Variant Prioritization Score for Impact Estimate 0.776
- REVEL 0.92
- CADD 26.90
- PolyPhen-2 1.00
- SIFT 0.00
- Population evidence available
- Structural context available
- ARAF Raf-like Ras-binding domain domainome 1.0: score -0.971